Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | MPO | P05164 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14612436 | 0.82 | TAAR1 (0.54) | TAAR1IDO1AGXTAPPKDM1A | |
| SCHEMBL25588040 | 0.80 | TAAR1 (0.52) | TAAR1IDO1AGXTKDM1AMPO | |
| SCHEMBL29086962 | 0.79 | TAAR1 (0.67) | TAAR1SLC6A2HRH2DRD3SLC6A3 | |
| SCHEMBL18664576 | 0.79 | AGXT (0.56) | TAAR1AGXTDRD3SRC | |
| SCHEMBL24870836 | 0.78 | TAAR1 (0.50) | TAAR1IDO1AGXTKDM1AMPO | |
| SCHEMBL30009921 | 0.78 | TAAR1 (0.66) | TAAR1IDO1AGXTMPOSCN8A | |
| SCHEMBL6896418 | 0.78 | TAAR1 (0.50) | TAAR1IDO1AGXTAPPKDM1A | |
| SCHEMBL31612206 | 0.78 | CYP3A4 (0.59) | TAAR1IDO1AGXTAPPKDM1A | |
| SCHEMBL20804366 | 0.78 | MPO (0.54) | TAAR1IDO1AGXTKDM1AMPO | |
| SCHEMBL4573287 | 0.78 | TAAR1 (0.50) | TAAR1IDO1AGXTKDM1AMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104245675-B | Cyclic amides as MetAP-2 inhibitors | 默克专利股份公司 | 2017-10-13 | — | — | CN | claimed |
| CN-104245675-A | Cyclic amides as MetAP-2 inhibitors | MERCK PATENT GMBH | 2014-12-24 | — | — | CN | claimed |
| WO-2024110608-A1 | PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | NEURALIS (BE) | 2024-05-30 | — | — | WO | disclosed |
| CN-104245675-B | Cyclic amides as MetAP-2 inhibitors | 默克专利股份公司 | 2017-10-13 | — | — | CN | disclosed |
| EP-3177603-A1 | PYRROLIDINONE DERIVATIVES AS METAP-2 INHIBITORS | Merck Patent GmbH (DE) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016020031-A1 | PYRROLIDINONE DERIVATIVES AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-02-11 | — | — | WO | disclosed |
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-104245675-A | Cyclic amides as MetAP-2 inhibitors | MERCK PATENT GMBH | 2014-12-24 | — | — | CN | disclosed |
| CN-103153951-A | Pyrrolidones as MetAP-2 inhibitors | MERCK PATENT GMBH | 2013-06-12 | — | — | CN | disclosed |
| CN-102753538-A | Sultam derivatives | HOFFMANN LA ROCHE | 2012-10-24 | — | — | CN | disclosed |
| CN-102532162-A | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2012-07-04 | — | — | CN | disclosed |
| WO-2008118758-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (GB) | 2008-10-02 | — | — | WO | disclosed |