Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976337 | 1.00 | HSP90AB1 (0.51) | HSP90AB1TDP1KDM4ELMNAGAA | |
| SCHEMBL4978489 | 0.94 | HSP90AB1 (0.51) | HSP90AB1KDM4ELMNASMN1; SMN2HRH3 | |
| SCHEMBL4978474 | 0.94 | HSP90AB1 (0.51) | HSP90AB1KDM4ELMNASMN1; SMN2HRH3 | |
| SCHEMBL4979716 | 0.90 | HSP90AB1 (0.42) | HSP90AB1MEN1MAPTKMT2ATLR9 | |
| SCHEMBL4979726 | 0.90 | HSP90AB1 (0.42) | HSP90AB1MEN1MAPTKMT2ATLR9 | |
| SCHEMBL4974875 | 0.90 | HPGD (0.51) | HSP90AB1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4974888 | 0.90 | HPGD (0.51) | HSP90AB1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4978885 | 0.88 | HSP90AB1 (0.42) | HSP90AB1KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4978895 | 0.88 | HSP90AB1 (0.42) | HSP90AB1KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4981967 | 0.88 | ALDH1A1 (0.46) | HSP90AB1GAASMN1; SMN2HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | HSP90AB1 2652/4885TDP1 899/4885KDM4E 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.