SCHEMBL497638

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4033042	0.91	KDM4E (0.59)	KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
	SCHEMBL28581732	0.87	KDM4E (0.62)	KDM4ECA1CA2EGFRMAPT
	SCHEMBL27921399	0.86	PLAU (0.53)	KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
	SCHEMBL9939070	0.86	CYP11B1 (0.55)	KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
	SCHEMBL16712674	0.86	EGFR (0.63)	KDM4ECA1CA2EGFRMAPT
	SCHEMBL12836646	0.83	CA1 (0.61)	KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
	SCHEMBL17707305	0.83	TDP1 (0.58)	KDM4ECA1CA2EGFRMAPT
	SCHEMBL497642	0.83	CA1 (0.61)	KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
	SCHEMBL3753608	0.82	KDM4E (0.59)	KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
	SCHEMBL2941838	0.82	PTGS1 (0.55)	KDM4ECA1CA2EGFRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.