Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | CA4 | P22748 | 6/20 | 0.50 |
| ▸ | CA9 | Q16790 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493064 | 0.87 | JAK2 (0.47) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL24328 | 0.84 | SIGMAR1 (0.56) | ALDH1A1SIGMAR1LMNAGAA | |
| SCHEMBL3494894 | 0.82 | CA1 (0.48) | CA1CA2CA4CA9SIGMAR1 | |
| SCHEMBL30483521 | 0.81 | SIGMAR1 (0.40) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL17154894 | 0.80 | GBA1 (0.43) | — | |
| SCHEMBL3495972 | 0.80 | SIGMAR1 (0.54) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL4971104 | 0.80 | SIGMAR1 (0.54) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL27533150 | 0.80 | CA1 (0.63) | CA1CA2CA4CA9 | |
| SCHEMBL20974922 | 0.80 | SIGMAR1 (0.54) | CA1CA2CA4CA9ALDH1A1 | |
| SCHEMBL26094131 | 0.79 | CA1 (0.50) | CA1CA2CA4CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |