Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.57 |
| ▸ | JAK2 | O60674 | 13/20 | 0.57 |
| ▸ | PLK4 | O00444 | 5/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976875 | 1.00 | JAK3 (0.57) | JAK3JAK2PLK4NTRK1PAK4 | |
| SCHEMBL4988399 | 0.85 | JAK3 (0.68) | JAK3JAK2 | |
| SCHEMBL4988403 | 0.85 | JAK3 (0.68) | JAK3JAK2 | |
| SCHEMBL4983862 | 0.84 | JAK3 (0.79) | JAK3JAK2PLK4NTRK1PAK4 | |
| SCHEMBL4983520 | 0.79 | JAK3 (0.63) | JAK3JAK2PLK4NTRK1PAK4 | |
| SCHEMBL4979167 | 0.78 | JAK2 (0.63) | JAK3JAK2PLK4NTRK1PAK4 | |
| SCHEMBL4983535 | 0.77 | JAK2 (0.61) | JAK3JAK2PLK4NTRK1PAK4 | |
| SCHEMBL4978667 | 0.77 | JAK3 (0.62) | JAK3JAK2PLK4PAK4 | |
| SCHEMBL13943453 | 0.76 | JAK3 (0.51) | JAK3JAK2PLK4NTRK1PAK4 | |
| SCHEMBL4981367 | 0.74 | JAK2 (0.57) | JAK3JAK2PLK4NTRK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |