Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784011 | 0.89 | HRH2 (0.52) | HRH2HRH1TSHRKMT2AMAPK1 | |
| SCHEMBL2799374 | 0.89 | HRH2 (0.52) | HRH2HRH1TSHRKMT2AMAPK1 | |
| SCHEMBL2801270 | 0.89 | HRH2 (0.52) | HRH2HRH1TSHRKMT2AMAPK1 | |
| SCHEMBL9718051 | 0.88 | HRH2 (0.48) | HRH2HRH1TSHRKMT2ACTSS | |
| SCHEMBL23845159 | 0.88 | HRH2 (0.48) | HRH2HRH1TSHRKMT2ACTSS | |
| SCHEMBL3741937 | 0.84 | CTSK (0.50) | HRH2HRH1TSHRKMT2AMAPK1 | |
| SCHEMBL6163781 | 0.83 | TSHR (0.48) | HRH2HRH1TSHRKMT2AMAPK1 | |
| SCHEMBL6163776 | 0.83 | TSHR (0.48) | HRH2HRH1TSHRKMT2AMAPK1 | |
| SCHEMBL8305402 | 0.81 | KMT2A (0.52) | HRH2HRH1KMT2AMAPK1CTSK | |
| SCHEMBL5141590 | 0.80 | TSHR (0.46) | HRH2HRH1TSHRKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968590-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |