Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916706 | 0.88 | KDM4E (0.72) | EZH2KDM4EGAACARM1PRMT6 | |
| SCHEMBL3916703 | 0.88 | EZH2 (0.59) | EZH2KDM4EGAAHDAC4HDAC6 | |
| SCHEMBL27628657 | 0.85 | HDAC4 (0.55) | EZH2KDM4EGAAHDAC4HDAC6 | |
| SCHEMBL20313801 | 0.84 | EZH2 (0.56) | EZH2KDM4EGAACARM1PRMT6 | |
| SCHEMBL11484910 | 0.84 | EZH2 (0.56) | EZH2KDM4EGAACARM1PRMT6 | |
| SCHEMBL9456941 | 0.84 | HDAC4 (0.57) | EZH2KDM4EGAAHDAC4HDAC6 | |
| SCHEMBL10526044 | 0.83 | EZH2 (0.52) | EZH2KDM4EGAAHDAC4HDAC6 | |
| SCHEMBL27800113 | 0.83 | MEN1 (0.50) | EZH2KDM4EGAAHDAC4HDAC6 | |
| SCHEMBL11638219 | 0.82 | EZH2 (0.54) | EZH2KDM4EGAACARM1PRMT6 | |
| SCHEMBL1414505 | 0.82 | HDAC4 (0.53) | EZH2KDM4EGAAHDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983987-A2 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007095188-A2 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-23 | — | — | WO | disclosed |
| US-4223147-A | POLYMER STABILIZERS | BAYER AKTIENGESELLSCHAFT (DE) | 1980-09-16 | — | — | US | disclosed |
| US-4178279-A | FIBERS AND FOILS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-12-11 | — | — | US | disclosed |
| US-4153596-A | PHOTOSTABILITY | BAYER AKTIENGESELLSCHAFT (DE) | 1979-05-08 | — | — | US | disclosed |
| US-4145512-A | Permanently stabilized polyurethanes | BAYER AKTIENGESELLSCHAFT (DE) | 1979-03-20 | — | — | US | disclosed |