Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267172 | 0.82 | CHRM5 (0.42) | KMT2AKDM4ENPSR1ATMTDP1 | |
| SCHEMBL4976844 | 0.80 | KMT2A (0.38) | KMT2ACYP3A4CYP2C19POLBPTGDR2 | |
| SCHEMBL4977915 | 0.78 | KDM4E (0.42) | KMT2AKDM4ENPSR1ATMTDP1 | |
| SCHEMBL2484248 | 0.73 | PTGDR2 (0.64) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL4974510 | 0.73 | CNR1 (0.49) | KMT2AKDM4ENPSR1MEN1ALDH1A1 | |
| SCHEMBL4979616 | 0.72 | KMT2A (0.37) | KMT2AKDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL4979166 | 0.72 | CYP1A2 (0.39) | KMT2AKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL4979426 | 0.72 | CNR1 (0.51) | KMT2AMEN1ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL4979970 | 0.72 | AKR1B1 (0.41) | KMT2AMEN1ALDH1A1GAACYP3A4 | |
| SCHEMBL20989112 | 0.72 | CYP2C19 (0.54) | KMT2AKDM4ENPSR1ATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984374-A1 | USE OF SPIRO Ý IMIDAZOLIDINE-4, 3'-INDOLE¨2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2008-10-29 | — | — | EP | claimed |
| WO-2007091946-A1 | USE OF SPIRO [ IMIDAZOLIDINE-4, 3'-INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | claimed |