Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980664 | 0.92 | KDM4E (0.55) | HSP90AB1KDM4EALDH1A1LRRK2TRPV6 | |
| SCHEMBL4976790 | 0.90 | HSP90AB1 (0.47) | HSP90AB1KDM4EALDH1A1LRRK2TP53 | |
| SCHEMBL4978537 | 0.90 | HSP90AB1 (0.52) | HSP90AB1ALDH1A1LRRK2HRH3 | |
| SCHEMBL4976987 | 0.90 | HSP90AB1 (0.51) | HSP90AB1LRRK2HRH3SLC6A4 | |
| SCHEMBL4976970 | 0.88 | PDE4B (0.56) | HSP90AB1KDM4EALDH1A1LRRK2 | |
| SCHEMBL4976713 | 0.87 | HSP90AB1 (0.49) | HSP90AB1GPR6HRH3SLC6A4 | |
| SCHEMBL4976464 | 0.87 | HSP90AB1 (0.51) | HSP90AB1KDM4EALDH1A1LRRK2HRH3 | |
| SCHEMBL4979037 | 0.87 | HSP90AB1 (0.55) | HSP90AB1KDM4EALDH1A1HRH3NPC1 | |
| SCHEMBL4980550 | 0.86 | HSP90AB1 (0.49) | HSP90AB1KDM4ENPC1RAB9A | |
| SCHEMBL4979696 | 0.86 | KDM4E (0.52) | HSP90AB1KDM4EALDH1A1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | HSP90AB1 2652/4885KDM4E 1865/4885ALDH1A1 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.