Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980664 | 0.90 | KDM4E (0.55) | KDM4EALDH1A1HTTGAAHSP90AB1 | |
| SCHEMBL4980322 | 0.89 | PKM (0.55) | KDM4EALDH1A1HSP90AB1PDGFRBPKM | |
| SCHEMBL4975954 | 0.88 | SMN1; SMN2 (0.50) | KDM4EALDH1A1KMT2AGAAHSP90AB1 | |
| SCHEMBL4976963 | 0.87 | MAPT (0.49) | KDM4EALDH1A1HTTKMT2AHSP90AB1 | |
| SCHEMBL4978008 | 0.86 | HSP90AB1 (0.47) | KDM4EALDH1A1HSP90AB1LRRK2 | |
| SCHEMBL4976790 | 0.86 | HSP90AB1 (0.47) | KDM4EALDH1A1KMT2AHSP90AB1MAPT | |
| SCHEMBL4978645 | 0.86 | HSP90AB1 (0.46) | KDM4EALDH1A1HTTKMT2AHSP90AB1 | |
| SCHEMBL4978462 | 0.86 | HSP90AB1 (0.44) | KDM4EHSP90AB1MAPT | |
| SCHEMBL4975968 | 0.86 | HSP90AB1 (0.51) | KDM4EALDH1A1GAAHSP90AB1MAPT | |
| SCHEMBL4976970 | 0.86 | PDE4B (0.56) | KDM4EALDH1A1HSP90AB1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | KDM4E 1865/4885ALDH1A1 1142/4885HTT 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.