Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.63 |
| ▸ | JAK2 | O60674 | 15/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980758 | 0.82 | JAK2 (0.80) | JAK3JAK2NTRK1 | |
| SCHEMBL13942386 | 0.80 | JAK3 (0.60) | JAK3JAK2NTRK1 | |
| SCHEMBL4022668 | 0.79 | JAK3 (0.60) | JAK3JAK2NTRK1 | |
| SCHEMBL4022675 | 0.79 | JAK3 (0.60) | JAK3JAK2NTRK1 | |
| SCHEMBL4985697 | 0.77 | JAK2 (1.00) | JAK3JAK2NTRK1 | |
| SCHEMBL4985342 | 0.77 | JAK2 (1.00) | JAK3JAK2NTRK1 | |
| SCHEMBL589401 | 0.76 | JAK3 (0.62) | JAK3JAK2NTRK1 | |
| SCHEMBL4982949 | 0.76 | JAK3 (1.00) | JAK3JAK2NTRK1AURKB | |
| SCHEMBL4978412 | 0.75 | JAK3 (1.00) | JAK3JAK2NTRK1AURKB | |
| SCHEMBL4021826 | 0.73 | JAK2 (0.73) | JAK3JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |