Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 1.00 |
| ▸ | JAK3 | P52333 | 16/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985342 | 1.00 | JAK2 (1.00) | JAK2JAK3NTRK1ALK | |
| SCHEMBL4981256 | 0.89 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL4980758 | 0.89 | JAK2 (0.80) | JAK2JAK3NTRK1 | |
| SCHEMBL4982863 | 0.87 | JAK3 (1.00) | JAK2JAK3NTRK1 | |
| SCHEMBL4982949 | 0.84 | JAK3 (1.00) | JAK2JAK3NTRK1 | |
| SCHEMBL3936781 | 0.84 | JAK2 (0.73) | JAK2JAK3NTRK1ALK | |
| SCHEMBL4021826 | 0.84 | JAK2 (0.73) | JAK2JAK3NTRK1ALK | |
| SCHEMBL4978412 | 0.80 | JAK3 (1.00) | JAK2JAK3NTRK1 | |
| SCHEMBL4983862 | 0.79 | JAK3 (0.79) | JAK2JAK3NTRK1 | |
| SCHEMBL4973163 | 0.78 | JAK2 (0.63) | JAK2JAK3NTRK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |