Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788542 | 0.84 | FAAH (0.35) | FAAHNR1H2HSP90AA1HSP90AB1MAP2K4 | |
| SCHEMBL25203731 | 0.82 | FAAH (0.34) | FAAHNR1H2HSP90AA1HSP90AB1MAP2K4 | |
| SCHEMBL161429 | 0.81 | FAAH (0.39) | FAAHNR1H2TUBB4ATUBBTUBA3C | |
| SCHEMBL2480409 | 0.79 | FAAH (0.38) | FAAHNR1H2HSP90AA1HSP90AB1MAP2K4 | |
| SCHEMBL19010764 | 0.78 | FAAH (0.38) | FAAHNR1H2TUBB4ATUBBTUBA3C | |
| SCHEMBL25519570 | 0.77 | MAP2K4 (0.40) | FAAHNR1H2HSP90AA1HSP90AB1MAP2K4 | |
| SCHEMBL18284944 | 0.77 | FAAH (0.39) | FAAHNR1H2HSP90AA1HSP90AB1MAP2K4 | |
| SCHEMBL25519814 | 0.77 | FAAH (0.39) | FAAHNR1H2HSP90AA1HSP90AB1MAP2K4 | |
| SCHEMBL2489522 | 0.75 | ELANE (0.39) | FAAHNR1H2ELANECTSDCTSE | |
| SCHEMBL20575911 | 0.74 | CFTR (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |