Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.48 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4205721 | 0.91 | HTR6 (0.58) | LMNAHTR6QRFPRALDH1A1SQSTM1 | |
| SCHEMBL4200890 | 0.88 | HTR6 (0.56) | LMNAKMT2ATSHRHTTNPSR1 | |
| SCHEMBL4205977 | 0.87 | HTR6 (0.58) | LMNAHTR6QRFPRALDH1A1KEAP1 | |
| SCHEMBL4201649 | 0.87 | HTR6 (0.58) | LMNAHTTHTR6QRFPRALDH1A1 | |
| SCHEMBL4211788 | 0.86 | HTR6 (0.56) | HTR6QRFPRSQSTM1KEAP1NFE2L2 | |
| SCHEMBL4204965 | 0.86 | HTR6 (0.54) | LMNAKMT2ATSHRHTTNPSR1 | |
| SCHEMBL4207489 | 0.86 | HTR6 (0.57) | LMNAHTR6QRFPRALDH1A1MAPT | |
| SCHEMBL4202828 | 0.86 | HTR6 (0.57) | LMNAKMT2AHTR6QRFPRALDH1A1 | |
| SCHEMBL4204559 | 0.86 | HTR6 (0.68) | LMNAKMT2AHTTHTR6QRFPR | |
| SCHEMBL4207178 | 0.86 | HTR6 (0.65) | HTR6QRFPRKEAP1NFE2L2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |