Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 7/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979050 | 0.93 | CHRM2 (0.45) | HRH1HRH3KDM2BCHRM2CHRM1 | |
| SCHEMBL4980602 | 0.92 | ALDH1A1 (0.42) | HRH1HRH3CHRM2CHRM1ALDH1A1 | |
| SCHEMBL4976132 | 0.92 | HRH3 (0.47) | HRH1HRH3CHRM2CHRM1ALDH1A1 | |
| SCHEMBL4976871 | 0.91 | HRH3 (0.40) | HRH1HRH3CHRM2CHRM1ALDH1A1 | |
| SCHEMBL4978589 | 0.88 | HRH1 (0.40) | HRH1HRH3KDM2BCHRM2CHRM1 | |
| SCHEMBL4978961 | 0.87 | HRH3 (0.39) | HRH1HRH3CHRM2CHRM1ALDH1A1 | |
| SCHEMBL4978021 | 0.85 | HRH1 (0.41) | HRH1HRH3KDM2BCHRM2CHRM1 | |
| SCHEMBL4978072 | 0.85 | HRH3 (0.43) | HRH1HRH3KDM2BALDH1A1LMNA | |
| SCHEMBL4978482 | 0.85 | OGA (0.41) | — | |
| SCHEMBL4978092 | 0.85 | ALDH1A1 (0.42) | HRH1HRH3KDM2BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | HRH1 4/4885HRH3 1/4885KDM2B 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.