Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.71 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mt-3995 SCHEMBL753911 | 0.83 | NR3C2 (1.00) | NR3C2BRD4ARPTGS2 | |
| SCHEMBL754239 | 0.80 | NR3C2 (0.71) | NR3C2BRD4ARCACNA1BAPBA1 | |
| SCHEMBL755189 | 0.80 | NR3C2 (0.70) | NR3C2BRD4ARCACNA1BAPBA1 | |
| SCHEMBL755350 | 0.80 | NR3C2 (0.70) | NR3C2BRD4ARCACNA1BAPBA1 | |
| SCHEMBL761147 | 0.80 | NR3C2 (0.70) | NR3C2BRD4ARCACNA1BAPBA1 | |
| SCHEMBL2266367 | 0.78 | NR3C2 (0.67) | NR3C2BRD4SCN9APGR | |
| SCHEMBL2269447 | 0.77 | NR3C2 (0.69) | NR3C2ARCACNA1BAPBA1LMNA | |
| SCHEMBL755391 | 0.77 | NR3C2 (0.72) | NR3C2BRD4ARCACNA1BAPBA1 | |
| SCHEMBL4530965 | 0.76 | NR3C2 (0.65) | NR3C2BRD4SCN9A | |
| SCHEMBL755900 | 0.76 | NR3C2 (0.71) | NR3C2BRD4ARCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007089034-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |