Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.70 |
| ▸ | PPOX | P50336 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.35 |
| ▸ | MTOR | P42345 | 5/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754239 | 0.88 | NR3C2 (0.71) | NR3C2BRD4PIK3CDPIK3R1MTOR | |
| SCHEMBL755350 | 0.87 | NR3C2 (0.70) | NR3C2BRD4PIK3CDPIK3R1MTOR | |
| SCHEMBL761147 | 0.87 | NR3C2 (0.70) | NR3C2BRD4PIK3CDPIK3R1MTOR | |
| SCHEMBL2266367 | 0.85 | NR3C2 (0.67) | NR3C2BRD4PIK3CDPIK3R1MTOR | |
| SCHEMBL4530965 | 0.84 | NR3C2 (0.65) | NR3C2BRD4 | |
| SCHEMBL5088338 | 0.83 | NR3C2 (0.67) | NR3C2BRD4PIK3CDPIK3R1MTOR | |
| Mt-3995 SCHEMBL753911 | 0.82 | NR3C2 (1.00) | NR3C2BRD4AR | |
| SCHEMBL2267353 | 0.80 | NR3C2 (0.56) | NR3C2PIK3CDARCACNA1BAPBA1 | |
| SCHEMBL4979414 | 0.80 | NR3C2 (0.71) | NR3C2BRD4ARCACNA1BAPBA1 | |
| SCHEMBL754848 | 0.79 | NR3C2 (0.59) | NR3C2BRD4ARCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | claimed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | claimed |
| US-7998956-B2 | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-08-16 | — | — | US | claimed |