Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497851 | 1.00 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL497850 | 1.00 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL497699 | 0.85 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL498060 | 0.85 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL497846 | 0.85 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL497845 | 0.85 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL497890 | 0.81 | PDE4B (0.57) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL498077 | 0.80 | PDE4D (0.48) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL3373175 | 0.75 | PDE4D (0.50) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL497992 | 0.74 | PDE4D (0.46) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157084-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | KOWA CO (JP) | 2013-05-22 | — | — | EP | disclosed |
| US-8106053-B2 | 5-phenyl-3-pyridazinone derivative | KOWA COMPANY, LTD. | 2012-01-31 | — | — | US | disclosed |
| US-20100197698-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| EP-2157084-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197698-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | SERPINE1, MMP1, PLAT | PDE4A 2167/4885PDE4D 2002/4885PDE4B 1932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.