Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 12/20 | 0.39 |
| ▸ | CA2 | P00918 | 12/20 | 0.39 |
| ▸ | CA4 | P22748 | 12/20 | 0.39 |
| ▸ | CA9 | Q16790 | 12/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3495888 | 0.90 | CA1 (0.42) | CA1CA2CA4CA9MGLL | |
| SCHEMBL3494077 | 0.90 | ABHD6 (0.52) | ABHD6DAGLA | |
| SCHEMBL4988386 | 0.86 | AVPR2 (0.41) | CA1CA2CA4CA9ABHD6 | |
| SCHEMBL3494999 | 0.84 | POLB (0.41) | CA1CA2CA4CA9MGLL | |
| SCHEMBL3494204 | 0.84 | POLB (0.41) | CA1CA2CA4CA9MGLL | |
| SCHEMBL3494080 | 0.83 | MDM2 (0.38) | SLC6A7MAPTMDM2KDM4E | |
| SCHEMBL3494753 | 0.82 | ABHD6 (0.49) | ABHD6DAGLAMAPTMGLL | |
| SCHEMBL3494932 | 0.82 | ABHD6 (0.49) | ABHD6DAGLAMAPTMGLL | |
| SCHEMBL3493856 | 0.82 | MEN1 (0.39) | CA1CA2CA4CA9ABHD6 | |
| SCHEMBL3494118 | 0.81 | CA1 (0.44) | CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |