Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14273302 | 0.85 | P2RX7 (0.36) | KMT2AMEN1KRASP2RX7KCNK3 | |
| SCHEMBL4978484 | 0.82 | KDM2B (0.50) | KMT2AMEN1ALDH1A1KDM4EP2RX7 | |
| SCHEMBL4976500 | 0.81 | P2RX7 (0.42) | PDE2AKMT2AMEN1P2RX7KCNK3 | |
| SCHEMBL4974572 | 0.81 | P2RX7 (0.43) | ALDH1A1KRASP2RX7KCNK3KCNK9 | |
| SCHEMBL4976388 | 0.81 | KDM2B (0.53) | KMT2AMEN1ALDH1A1KDM4EP2RX7 | |
| SCHEMBL4979585 | 0.80 | KDM4E (0.39) | PDE2AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL4978694 | 0.80 | KDM2B (0.52) | ALDH1A1P2RX7HRH1HRH3LMNA | |
| SCHEMBL4980177 | 0.80 | KCNK3 (0.49) | ALDH1A1KDM4EP2RX7KCNK3KCNK9 | |
| SCHEMBL4974700 | 0.79 | TLR7 (0.40) | KMT2AMEN1ALDH1A1KRASP2RX7 | |
| SCHEMBL4980362 | 0.79 | HRH3 (0.39) | KMT2AMEN1ALDH1A1KRASP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | PDE2A 2287/4885KMT2A 1417/4885MEN1 4419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.