Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 11/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492893 | 0.84 | FAAH (0.41) | FAAHCA1CA2CA4CA9 | |
| SCHEMBL3492897 | 0.78 | CA1 (0.38) | FAAHCA1CA2CA4CA9 | |
| SCHEMBL8237503 | 0.75 | NR1H2 (0.46) | FAAHNR1H2NR1H3 | |
| SCHEMBL3494779 | 0.73 | CA1 (0.43) | FAAHCA1CA2CA4CA9 | |
| SCHEMBL3494032 | 0.72 | CA1 (0.39) | CA1CA2CA4CA9NR1H2 | |
| SCHEMBL3493304 | 0.72 | CA1 (0.35) | FAAHCA1CA2CA4CA9 | |
| SCHEMBL27533150 | 0.71 | CA1 (0.63) | CA1CA2CA4CA9 | |
| SCHEMBL5141229 | 0.71 | CA1 (0.42) | CA1CA2CA4CA9NR1H2 | |
| SCHEMBL3494880 | 0.70 | CA1 (0.41) | CA1CA2CA4CA9 | |
| SCHEMBL3492546 | 0.69 | CA1 (0.40) | CA1CA2CA4CA9NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |