Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980588 | 0.94 | HSP90AB1 (0.45) | KDM4ESMN1; SMN2ALDH1A1NPC1HCRTR1 | |
| SCHEMBL4980707 | 0.92 | HSP90AB1 (0.51) | KDM4EALDH1A1HCRTR1HCRTR2HSP90AB1 | |
| SCHEMBL4979003 | 0.89 | HSP90AB1 (0.45) | HCRTR1HCRTR2HSP90AB1MAPTHSP90AA1 | |
| SCHEMBL4978905 | 0.88 | LMNA (0.47) | KDM4ESMN1; SMN2HCRTR1HCRTR2HSP90AB1 | |
| SCHEMBL4979010 | 0.88 | HSP90AB1 (0.45) | HCRTR1HCRTR2HSP90AB1MAPT | |
| SCHEMBL4980539 | 0.87 | HSP90AB1 (0.48) | HCRTR1HCRTR2HSP90AB1MAPTHSP90AA1 | |
| SCHEMBL4978732 | 0.86 | HSP90AB1 (0.51) | HCRTR1HCRTR2HSP90AB1MAPTHSP90AA1 | |
| SCHEMBL4978679 | 0.86 | HSP90AB1 (0.44) | HCRTR1HCRTR2HSP90AB1MAPTHSP90AA1 | |
| SCHEMBL14273428 | 0.85 | HSP90AB1 (0.50) | HCRTR1HCRTR2HSP90AB1MAPT | |
| SCHEMBL4979568 | 0.85 | HSP90AB1 (0.49) | HCRTR1HCRTR2HSP90AB1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | KDM4E 1865/4885SMN1; SMN2 3880/4885ALDH1A1 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.