Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980445 | 1.00 | ROCK1 (0.61) | ROCK1MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL4968833 | 0.88 | ROCK1 (0.45) | ROCK1MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL4968824 | 0.88 | ROCK1 (0.45) | ROCK1MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL4007663 | 0.87 | ROCK1 (0.56) | ROCK1MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL4007667 | 0.87 | ROCK1 (0.56) | ROCK1MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL4965892 | 0.81 | ROCK1 (0.59) | ROCK1ROCK2PRKXPRKCEPRKCD | |
| SCHEMBL4965898 | 0.81 | ROCK1 (0.59) | ROCK1ROCK2PRKXPRKCEPRKCD | |
| SCHEMBL8938507 | 0.81 | ROCK1 (0.76) | ROCK1PARP1ROCK2PRKXPRKCE | |
| SCHEMBL30283494 | 0.79 | MTNR1A (0.46) | ROCK1MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL4009155 | 0.77 | CHEK2 (0.48) | ROCK1MTNR1AMTNR1BCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963304-A1 | ISOQUINOLINE DERIVATIVES | N.V. Organon (NL) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007065916-A1 | ISOQUINOLINE DERIVATIVES | N.V. ORGANON (NL) | 2007-06-14 | — | — | WO | disclosed |