SCHEMBL4981189

SCHEMBL4981189

Cc1cc(C(=O)N2CCN(C(=O)O)C[C@@H]2Cc2ccccc2O)c(-c2ccccc2)n1-c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
NOTUM Q6P988 1/20 0.37
SMN1; SMN2 Q16637 4/20 0.37
NPC1 O15118 3/20 0.37
RAB9A P51151 3/20 0.37
MAPT P10636 1/20 0.37
CA1 P00915 12/20 0.36
CA2 P00918 12/20 0.36
CA4 P22748 12/20 0.36
CA9 Q16790 12/20 0.36
CNR2 P34972 2/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
CNR1 P21554 1/20 0.33
POLB P06746 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3495460 0.87 CA1 (0.40) ALDH1A1NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL3492063 0.87 ALDH1A1 (0.41) ALDH1A1NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL3493355 0.85 CA1 (0.44) CA1CA2CA4CA9
SCHEMBL3495346 0.84 SMN1; SMN2 (0.41) ALDH1A1NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL3493841 0.84 ALDH1A1 (0.39) ALDH1A1NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL3494880 0.84 CA1 (0.41) CA1CA2CA4CA9
SCHEMBL3494368 0.84 CA1 (0.41) CA1CA2CA4CA9
SCHEMBL3493449 0.83 SMN1; SMN2 (0.42) ALDH1A1NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL3493665 0.83 BCL2 (0.38) ALDH1A1NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL4982310 0.82 ALDH1A1 (0.37) ALDH1A1NOTUMSMN1; SMN2MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1984355-A2 CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION Takeda Pharmaceutical Company Limited (JP) 2008-10-29 EP disclosed
WO-2007094513-A2 CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-23 WO disclosed