Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL560636 | 0.94 | GPR119 (0.55) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL1576008 | 0.90 | GPR119 (0.56) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL23499817 | 0.88 | GPR119 (0.57) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL8430037 | 0.88 | GPR119 (0.57) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL2187082 | 0.87 | GPR119 (0.49) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL7920172 | 0.87 | GPR119 (0.49) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL23006759 | 0.87 | GPR119 (0.49) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL15085741 | 0.86 | GPR119 (0.59) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL310405 | 0.85 | HPGD (0.54) | GPR119FAAHHPGDKDM4EPKM | |
| SCHEMBL31662254 | 0.85 | HPGD (0.54) | GPR119FAAHHPGDKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989200-A2 | [4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELI LILLY AND COMPANY (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007092095-A2 | [4-(BENZO [B] THI0PHEN-2-YL) PYRIMIDIN-2YL] -AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES. | ELI LILLY AND COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |