Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 1.00 |
| ▸ | JAK2 | O60674 | 18/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | MUSK | O15146 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.54 |
| ▸ | STAT5B | P51692 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4978285 | 0.92 | JAK3 (1.00) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4983441 | 0.91 | JAK3 (1.00) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4982949 | 0.91 | JAK3 (1.00) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL13943149 | 0.85 | JAK3 (0.74) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4979068 | 0.84 | JAK3 (0.73) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4978412 | 0.83 | JAK3 (1.00) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4980719 | 0.76 | JAK3 (0.74) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4983707 | 0.76 | JAK3 (0.73) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4983713 | 0.76 | JAK3 (0.74) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL4980320 | 0.76 | JAK3 (0.78) | JAK3JAK2NTRK1AURKBRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |