Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494934 | 0.88 | POLB (0.36) | MGLLALDH1A1SPHK2LMNAKMT2A | |
| SCHEMBL3494754 | 0.88 | POLB (0.36) | MGLLALDH1A1SPHK2LMNAKMT2A | |
| SCHEMBL3492728 | 0.83 | SPHK2 (0.41) | FAAHMGLLALDH1A1SPHK2SPHK1 | |
| SCHEMBL3493899 | 0.82 | DHODH (0.36) | MGLLALDH1A1SPHK2SPHK1KDM4E | |
| SCHEMBL3494080 | 0.81 | MDM2 (0.38) | KDM4EMAPT | |
| SCHEMBL4982247 | 0.79 | ABHD6 (0.46) | FAAHMGLLSPHK2 | |
| SCHEMBL3492193 | 0.77 | AVPR2 (0.39) | MGLLALDH1A1KMT2A | |
| SCHEMBL3491863 | 0.74 | CA1 (0.40) | — | |
| SCHEMBL3495945 | 0.72 | NOTUM (0.34) | FAAHALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4978695 | 0.72 | CYP2D6 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |