Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 1.00 |
| ▸ | JAK2 | O60674 | 16/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4981256 | 0.89 | JAK2 (1.00) | JAK3JAK2 | |
| SCHEMBL4983862 | 0.88 | JAK3 (0.79) | JAK3JAK2AURKAAURKBNTRK1 | |
| SCHEMBL4985342 | 0.87 | JAK2 (1.00) | JAK3JAK2NTRK1 | |
| SCHEMBL4985697 | 0.87 | JAK2 (1.00) | JAK3JAK2NTRK1 | |
| SCHEMBL4980758 | 0.79 | JAK2 (0.80) | JAK3JAK2NTRK1 | |
| SCHEMBL4970845 | 0.79 | JAK2 (0.64) | JAK3JAK2 | |
| SCHEMBL13942616 | 0.78 | JAK3 (0.75) | JAK3JAK2AURKAAURKBNTRK1 | |
| SCHEMBL4983520 | 0.78 | JAK3 (0.63) | JAK3JAK2NTRK1PLK4 | |
| SCHEMBL4979167 | 0.77 | JAK2 (0.63) | JAK3JAK2NTRK1PLK4 | |
| SCHEMBL4978667 | 0.77 | JAK3 (0.62) | JAK3JAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |