SCHEMBL498292

SCHEMBL498292

COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCCc2cccnc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 3/20 1.00
KCNH2 Q12809 1/20 1.00
KCNA5 P22460 2/20 0.60
KCNK5 O95279 1/20 0.60
KCNK17 Q96T54 1/20 0.60
KCNK9 Q9NPC2 1/20 0.60
KMT2A Q03164 3/20 0.54
NPC1 O15118 1/20 0.50
PTPN1 P18031 2/20 0.48
SLC6A5 Q9Y345 2/20 0.48
GAA P10253 1/20 0.48
KCNA3 P22001 1/20 0.47
PTAFR P25105 1/20 0.47
LMNA P02545 1/20 0.47
DGAT2 Q96PD7 1/20 0.47
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29778218 1.00 KCNK3 (1.00) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434086 0.92 KCNK3 (0.84) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434102 0.90 KCNK3 (0.81) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434454 0.90 KCNK3 (0.81) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL726554 0.87 KCNK3 (0.77) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434083 0.84 KCNK3 (0.73) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434461 0.84 KCNK3 (0.72) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434141 0.83 KCNK3 (0.71) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434450 0.82 KCNK3 (0.73) KCNK3KCNH2KCNA5KCNK5KCNK17
SCHEMBL12434153 0.80 KCNK3 (0.67) KCNK3KCNH2KCNA5KMT2AKCNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025068591-A1 INTRANASAL FORMULATIONS FOR TREATING OBSTRUCTIVE SLEEP APNEA MOSANNA THERAPEUTICS AG (CH) 2025-04-03 WO claimed
US-9056833-B2 Crystalline phases of 2′-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2015-06-16 US claimed
US-20120071520-A1 CRYSTALLINE PHASES OF 2'--BIPHENYL-2-CARBOXYLIC ACID (2-PYRIDIN-3-YL-ETHYL)-AMIDE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-03-22 US claimed
US-8106099-B2 2'-{[2-(4-methoxyphenyl)acetylamino]methyl}biphenyl-2-carboxylic acid (2-pyridin-3-ylethyl)amide or other phenylcarboxamide derivatives with dofetilide, ibutilide, almokalant, sotalol, azimilide, amiodarone, E4031, clofilium, ambasilide, MS551, tedisamil, bertosamil and quinidine as IKr chahel blocker SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-01-31 US claimed
US-20090149496-A1 INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-06-11 US claimed
EP-2012758-A2 INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL Sanofi-Aventis Deutschland GmbH (DE) 2009-01-14 EP claimed
WO-2007124849-A2 INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-11-08 WO claimed
US-20070043091-A1 Kv1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-02-22 US claimed
WO-2025082731-A1 INTRANASAL FORMULATIONS FOR TREATING OBSTRUCTIVE SLEEP APNEA MOSANNA THERAPEUTICS AG (CH) 2025-04-24 WO disclosed
WO-2025068591-A1 INTRANASAL FORMULATIONS FOR TREATING OBSTRUCTIVE SLEEP APNEA MOSANNA THERAPEUTICS AG (CH) 2025-04-03 WO disclosed
EP-2438045-B1 CRYSTALLINE PHASES OF 2'-{[2-(4-METHOXY-PHENYL)-ACETYLAMINO]-METHYL}-BIPHENYL-2-CARBOXYLIC ACID (2-PYRIDIN-3-YL-ETHYL)-AMIDE SANOFI AVENTIS DEUTSCHLAND (DE) 2016-10-05 EP disclosed
US-9056833-B2 Crystalline phases of 2′-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2015-06-16 US disclosed
US-20120071520-A1 CRYSTALLINE PHASES OF 2'--BIPHENYL-2-CARBOXYLIC ACID (2-PYRIDIN-3-YL-ETHYL)-AMIDE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-03-22 US disclosed
US-20120071520-A1 CRYSTALLINE PHASES OF 2'--BIPHENYL-2-CARBOXYLIC ACID (2-PYRIDIN-3-YL-ETHYL)-AMIDE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2012-03-22 US disclosed
WO-2007124849-A2 INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-11-08 WO disclosed
WO-2007124849-A2 INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-11-08 WO disclosed
US-20070043091-A1 Kv1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-02-22 US disclosed
US-20070043091-A1 Kv1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-02-22 US disclosed
US-20070043091-A1 Kv1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-02-22 US disclosed
WO-2005025674-A1 COMBINATION OF PHENYLCARBOXAMIDES WITH BETA-ADRENERGIC RECEPTOR BLOCKERS AND USE THEREOF FOR THE TREATMENT OF ATRIAL ARRHYTHMIAS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-03-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071520-A1 CRYSTALLINE PHASES OF 2'--BIPHENYL-2-CARBOXYLIC ACID (2-PYRIDIN-3-YL-ETHYL)-AMIDE HRH2, CTSH, HRH1 KCNK3 3825/4885KCNH2 1199/4885KCNA5 3165/4885
US-20090149496-A1 INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL KCNN3, CACNA1I, KCNN1 KCNK3 18/4885KCNH2 80/4885KCNA5 67/4885
US-20070043091-A1 Kv1.5-BLOCKER FOR THE SELECTIVE INCREASE OF ATRIAL CONTRACTILITY AND TREATMENT OF CARDIAC INSUFFICIENCY KCNJ2, KCNH2, KCNK5 KCNK3 31/4885KCNH2 2/4885KCNA5 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.