Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | MGAM | O43451 | 1/20 | 0.58 |
| ▸ | SI | P14410 | 1/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL54877 | 0.96 | GAA (0.64) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL28359032 | 0.93 | GAA (0.61) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL30381316 | 0.93 | GAA (0.61) | GAAMGAMSIMGAM2ALDH1A1 | |
| Formaldehyde SCHEMBL459758 | 0.91 | GAA (0.58) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL7729694 | 0.89 | GAA (0.56) | GAAMGAMSIMGAM2ALDH1A1 | |
| Trimethylammonium SCHEMBL10940613 | 0.89 | GAA (0.56) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL28650988 | 0.89 | GAA (0.74) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL28539237 | 0.88 | GAA (0.54) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL155563 | 0.86 | GAA (0.78) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL29980003 | 0.84 | GAA (0.61) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070789-A1 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | SLANINA PAVEL | 2008-03-20 | — | — | US | disclosed |
| US-20060167265-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | PETERS THEODORUS H | 2006-07-27 | — | — | US | disclosed |
| EP-1577298-A1 | Process for determining the purity of amlodipine | Bioorganics B.V. (NL) | 2005-09-21 | — | — | EP | disclosed |
| US-20050137405-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | PETERS THEODORUS H A (NL) | 2005-06-23 | — | — | US | disclosed |
| US-6858738-B2 | Process for making amlodipine, derivatives thereof, and precursors therefor | SYNTHON BV (NL) | 2005-02-22 | — | — | US | disclosed |
| US-20030220501-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | SYNTHON IP INC. | 2003-11-27 | — | — | US | disclosed |
| US-6653481-B2 | Used as calcium channel blockers | SYNTHON BV (NL) | 2003-11-25 | — | — | US | disclosed |
| EP-1345901-A2 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | Bioorganics B.V. (NL) | 2003-09-24 | — | — | EP | disclosed |
| US-20020143046-A1 | Process for making amlodipine, derivatives therof, and precursors therefor | SYNTHON IP INC. | 2002-10-03 | — | — | US | disclosed |
| WO-2002053535-A2 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | BIOORGANICS B.V. (NL) | 2002-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167265-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | CYP4A11, CYP4F11, CACNA1D | GAA 3690/4885MGAM 1280/4885SI 2264/4885 |
| US-20050137405-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | CACNA1D, CACNA1S, CACNA1C | GAA 4093/4885MGAM 3894/4885SI 3626/4885 |
| US-20030220501-A1 | Process for making amlodipine, derivatives thereof, and precursors therefor | CACNA1D, CACNA1S, CACNA1C | GAA 3822/4885MGAM 3632/4885SI 3317/4885 |
| US-20020143046-A1 | Process for making amlodipine, derivatives therof, and precursors therefor | CACNA1D, CACNA1F, CACNA1S | GAA 3702/4885MGAM 4321/4885SI 3479/4885 |
| US-20080070789-A1 | PROCESS FOR MAKING AMLODIPINE, DERIVATIVES THEREOF, AND PRECURSORS THEREFOR | CACNA1D, CACNA1F, CYP51A1 | GAA 2791/4885MGAM 1778/4885SI 3237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.