Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 10/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL349314 | 0.89 | FFAR1 (0.71) | FFAR1KEAP1MAP4K4FFAR4PDPK1 | |
| Hydrochloric Acid SCHEMBL11045221 | 0.87 | FFAR1 (0.69) | FFAR1KEAP1MAP4K4FFAR4PDPK1 | |
| SCHEMBL4979314 | 0.86 | PLAAT3 (0.45) | FFAR1PDPK1MEN1KMT2APLAAT3 | |
| SCHEMBL1697834 | 0.85 | FFAR1 (0.68) | FFAR1KEAP1FFAR4MEN1KMT2A | |
| SCHEMBL19914066 | 0.82 | FFAR1 (0.65) | FFAR1KEAP1FFAR4KMT2A | |
| SCHEMBL11565077 | 0.81 | CYP26A1 (0.51) | MEN1KMT2ACA2 | |
| Alcohol SCHEMBL7860672 | 0.81 | FFAR1 (0.63) | FFAR1KEAP1MAP4K4FFAR4PDPK1 | |
| SCHEMBL4982350 | 0.80 | CYP11B1 (0.51) | FFAR1MEN1KMT2APLAAT3PLAAT5 | |
| Guanidine SCHEMBL5348315 | 0.80 | FFAR1 (0.61) | FFAR1KEAP1MAP4K4FFAR4PDPK1 | |
| SCHEMBL19914070 | 0.78 | FFAR1 (0.59) | FFAR1KEAP1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348433-B2 | Quinolinones as prostaglandin receptor ligands | MERCK FROSST CANADA & CO. (CA) | 2008-03-25 | — | — | US | disclosed |
| EP-1458718-B1 | QUINOLINONES AS PROSTAGLANDIN RECEPTOR LIGANDS | MERCK FROSST CANADA LTD (CA) | 2006-10-25 | — | — | EP | disclosed |
| US-20050222194-A1 | Quinolinones as prostaglandin receptor ligands | MERCK FROSST CANADA LTD. (CA) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222194-A1 | Quinolinones as prostaglandin receptor ligands | PTGFR, PTGER1, PTGER2 | FFAR1 71/4885KEAP1 878/4885MAP4K4 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.