Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3495062 | 0.83 | REN (0.47) | RENHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL13340161 | 0.82 | KAT7 (0.38) | — | |
| SCHEMBL8236184 | 0.81 | HCRTR1 (0.53) | RENHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3494532 | 0.80 | HCRTR1 (0.44) | RENKCNH2HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3493364 | 0.80 | KDM1A (0.35) | — | |
| Hydrochloric Acid SCHEMBL3494081 | 0.80 | HCRTR1 (0.52) | RENHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3493823 | 0.79 | HCRTR1 (0.48) | RENHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL13341376 | 0.79 | HCRTR1 (0.45) | RENHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL13341403 | 0.79 | HCRTR1 (0.44) | RENHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL4985477 | 0.79 | CNR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |