Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4992361 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP2A6CYP3A4KMT2AKDM4E | |
| SCHEMBL4984561 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2A6KMT2AGRM1KDM4E | |
| SCHEMBL4989915 | 0.85 | KMT2A (0.43) | SMN1; SMN2CYP2A6CYP3A4KMT2AKDM4E | |
| SCHEMBL27699823 | 0.81 | KMT2A (0.47) | SMN1; SMN2CYP2A6CYP3A4KMT2AKDM4E | |
| SCHEMBL4932097 | 0.80 | MARS1 (0.53) | SMN1; SMN2CYP2A6CYP3A4KMT2AMDM2 | |
| SCHEMBL4987515 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AKDM4EHSD17B10 | |
| SCHEMBL4982026 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL27682302 | 0.73 | CYP2A6 (0.47) | CYP2A6CYP3A4KMT2APIM1MDM2 | |
| SCHEMBL4923262 | 0.73 | CYP3A4 (0.44) | SMN1; SMN2CYP2A6CYP3A4KMT2AMAPT | |
| SCHEMBL4988249 | 0.72 | KMT2A (0.46) | SMN1; SMN2CYP2A6KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125409-A1 | 1,5-Diheterocycle-1H-Triazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-05-29 | — | — | US | disclosed |
| US-20080125409-A1 | 1,5-Diheterocycle-1H-Triazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-05-29 | — | — | US | disclosed |
| US-20080125409-A1 | 1,5-Diheterocycle-1H-Triazole Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-05-29 | — | — | US | disclosed |
| CN-101039934-A | 1, 5-diheterocyclic-1H-triazole derivatives | DAIICHI SEIYAKU CO (JP) | 2007-09-19 | — | — | CN | disclosed |
| EP-1803719-A1 | 1,5-DIHETEROCYCLE-1H-TRIAZOLE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-07-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125409-A1 | 1,5-Diheterocycle-1H-Triazole Derivative | PTGS1, PTGER1, TBXA2R | SMN1; SMN2 3713/4885CYP2A6 561/4885CYP3A4 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.