Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | LDHB | P07195 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12256512 | 0.81 | RET (0.46) | KDRRPS6KB1 | |
| SCHEMBL29370429 | 0.79 | KDM4E (0.57) | EGFRKDRMEN1KMT2AALDH1A1 | |
| SCHEMBL2459579 | 0.78 | RXFP1 (0.55) | EGFRKDRMEN1KMT2AALDH1A1 | |
| SCHEMBL4986819 | 0.77 | CSNK2A1 (0.51) | CSNK2A1CSNK2A2CSNK2BKDM5BLDHA | |
| SCHEMBL4991734 | 0.77 | CSNK2A1 (0.51) | CSNK2A1CSNK2A2CSNK2BKDM5BKDR | |
| SCHEMBL4990856 | 0.77 | CSNK2A1 (0.54) | CSNK2A1CSNK2A2CSNK2BKDM5BLDHA | |
| SCHEMBL4990576 | 0.77 | CSNK2A1 (0.54) | CSNK2A1CSNK2A2CSNK2BKDM5BLDHA | |
| SCHEMBL4997771 | 0.74 | CSNK2A1 (0.51) | CSNK2A1CSNK2A2CSNK2BKDM5BLDHA | |
| SCHEMBL5067187 | 0.73 | EGFR (0.52) | KDM5BEGFRKDRMEN1KMT2A | |
| SCHEMBL4972165 | 0.72 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349836-B2 | Phthalazine derivatives as inhibitors of protein kinase | ARALDI GIAN-LUCA (US) | 2013-01-08 | — | — | US | claimed |
| US-20080146547-A1 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-06-19 | — | — | US | claimed |
| US-8349836-B2 | Phthalazine derivatives as inhibitors of protein kinase | ARALDI GIAN-LUCA (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | disclosed |
| US-20080146547-A1 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-06-19 | — | — | US | disclosed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146547-A1 | PHTHALAZINE DERIVATIVES | CDK5, HIPK2, PACSIN2 | CSNK2A1 60/4885CSNK2A2 59/4885CSNK2B 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.