Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494477 | 0.89 | USP30 (0.39) | — | |
| SCHEMBL3495602 | 0.83 | CYP11B2 (0.34) | CYP11B2PTGS2CTDSP1TDP1 | |
| SCHEMBL3496018 | 0.83 | CYP11B2 (0.35) | CYP11B2PTGS2KDM4AKDM5AKDM4C | |
| SCHEMBL3493922 | 0.81 | CYP11B2 (0.34) | CYP11B2PTGS2CTDSP1TDP1 | |
| SCHEMBL3493920 | 0.81 | CYP11B2 (0.34) | CYP11B2PTGS2CTDSP1TDP1 | |
| SCHEMBL3495160 | 0.81 | CYP11B2 (0.34) | CYP11B2PTGS2 | |
| SCHEMBL3494480 | 0.79 | CYP11B2 (0.35) | CYP11B2KDM4AKDM5AKDM4CKDM5B | |
| SCHEMBL4982236 | 0.76 | HCRTR2 (0.31) | PTGS2 | |
| SCHEMBL3494313 | 0.76 | POLB (0.34) | — | |
| SCHEMBL3491411 | 0.75 | CYP11B2 (0.49) | CYP11B2PTGS2KDM4AKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |