⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24459 | 0.94 | — | — | |
| SCHEMBL4778229 | 0.89 | — | — | |
| Ammonia Solution, Strong SCHEMBL9538468 | 0.89 | ALDH1A1 (0.31) | — | |
| SCHEMBL4777357 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL237157 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL546609 | 0.89 | — | — | |
| Ammonia Solution, Strong SCHEMBL1138722 | 0.89 | ALDH1A1 (0.31) | — | |
| Bromide SCHEMBL7178493 | 0.89 | — | — | |
| SCHEMBL21385109 | 0.89 | — | — | |
| Hydrazine SCHEMBL3475792 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10219129-A | — | — | None | — | — | JP | disclosed |
| WO-2023200364-A1 | METHODS FOR PRODUCING (1R,2S,5S)-N-[(1S)-1-CYANO-2-[(3S)-2-OXOPYRROLIDIN-3-YL]ETHYL]-3-[(2S)-3,3-DIMETHYL-2-[(2,2,2-TRIFLUOROACETYL)AMINO]BUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ПРОМОМЕД РУС" | 2023-10-19 | — | — | WO | disclosed |
| US-9415088-B2 | Use of AGR3 for treating cancer | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-08-16 | — | — | US | disclosed |
| US-20160051671-A1 | COMBINATION OF BLyS INHIBITION AND ANTI-CD 20 AGENTS FOR TREATMENT OF AUTOIMMUNE DISEASE | ARES TRADING S.A. (CH) | 2016-02-25 | — | — | US | disclosed |
| EP-2233149-B1 | Combination of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and anti-CD20 agents for treatment of autoimmune disease | ZYMOGENETICS INC (US) | 2016-02-10 | — | — | EP | disclosed |
| EP-1631313-B1 | COMBINATION THERAPY FOR B CELL DISORDERS | GENENTECH INC (US) | 2015-03-11 | — | — | EP | disclosed |
| EP-2272868-B1 | Combination therapy for B cell disorders | GENENTECH INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8956611-B2 | Combination of BLyS inhibition and anti-CD 20 agents for treatment of autoimmune disease | ZYMOGENETICS, INC. (US) | 2015-02-17 | — | — | US | disclosed |
| US-20140377257-A1 | COMBINATION THERAPY FOR B CELL DISORDERS | GENENTECH, INC. (US) | 2014-12-25 | — | — | US | disclosed |
| US-8852591-B2 | Combination of BLyS and/or APRIL inhibition and immunosuppressants for treatment of autoimmune disease | ZYMOGENETICS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-0229108-B1 | SOLUBILIZATION OF PROTEINS FOR PHARMACEUTICAL COMPOSITIONS USING POLYMER CONJUGATION | CETUS CORPORATION (US) | 1990-12-27 | — | — | EP | disclosed |
| EP-0402378-A1 | CONJUGATION OF POLYMER TO COLONY STIMULATING FACTOR-1. | CETUS CORP (US) | 1990-12-19 | — | — | EP | disclosed |
| US-4917888-A | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation | CETUS CORPORATION (US) | 1990-04-17 | — | — | US | disclosed |
| WO-1989006546-A1 | CONJUGATION OF POLYMER TO COLONY STIMULATING FACTOR-1 | CETUS CORPORATION (US) | 1989-07-27 | — | — | WO | disclosed |
| US-4847325-A | PROTEINS | CETUS CORPORATION (US) | 1989-07-11 | — | — | US | disclosed |
| US-4818769-A | TREATING SHIPPING FEVER, USING THE POLYPEPTIDE BONDED POLYOXYETHYLENE GLYCOL | CETUS CORPORATION (US) | 1989-04-04 | — | — | US | disclosed |
| US-4766106-A | Solubilization of proteins for pharmaceutical compositions using polymer conjugation | CETUS CORPORATION (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0247860-A2 | Tumor necrosis factor formulation and its preparation | CETUS ONCOLOGY CORPORATION (US) | 1987-12-02 | — | — | EP | disclosed |
| EP-0229108-A1 | SOLUBILIZATION OF PROTEINS FOR PHARMACEUTICAL COMPOSITIONS USING POLYMER CONJUGATION. | CETUS CORP (US) | 1987-07-22 | — | — | EP | disclosed |
| WO-1987000056-A1 | SOLUBILIZATION OF PROTEINS FOR PHARMACEUTICAL COMPOSITIONS USING POLYMER CONJUGATION | CETUS CORPORATION (US) | 1987-01-15 | — | — | WO | disclosed |