Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 1.00 |
| ▸ | MTOR | P42345 | 15/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.50 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986325 | 0.89 | MTOR (1.00) | PIK3CAMTORPIK3R1ALDH1A1HPGD | |
| SCHEMBL3992072 | 0.83 | PIK3CA (1.00) | PIK3CAMTORALDH1A1HPGDHSD17B10 | |
| SCHEMBL3989565 | 0.82 | PIK3CA (1.00) | PIK3CAMTORALDH1A1HPGDHSD17B10 | |
| SCHEMBL10143799 | 0.82 | PIK3CA (0.76) | PIK3CAMTORALDH1A1HPGDHSD17B10 | |
| SCHEMBL3986815 | 0.80 | PIK3CA (0.75) | PIK3CAMTORALDH1A1HPGDHSD17B10 | |
| SCHEMBL4991670 | 0.80 | PIK3CA (0.78) | PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL4996533 | 0.79 | PIK3CA (0.86) | PIK3CAMTORPIK3R1 | |
| SCHEMBL3991968 | 0.79 | PIK3CA (0.82) | PIK3CAMTORPIK3R1 | |
| SCHEMBL3992571 | 0.79 | MTOR (0.75) | PIK3CAMTORALDH1A1HPGDHSD17B10 | |
| SCHEMBL3988528 | 0.79 | PIK3CA (0.77) | PIK3CAMTORALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | PIK3CA 2/4885MTOR 1/4885PIK3R1 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.