Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 6/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | HPGDS | O60760 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989884 | 0.89 | C3AR1 (0.47) | C3AR1ROCK2HPGDSHDAC3HDAC4 | |
| SCHEMBL14090971 | 0.86 | C3AR1 (0.41) | C3AR1ROCK2HPGDSRXFP1HDAC3 | |
| SCHEMBL14147012 | 0.85 | HPGDS (0.49) | C3AR1ROCK2HPGDSHDAC3HDAC4 | |
| SCHEMBL4989589 | 0.78 | C3AR1 (0.47) | C3AR1ROCK2HPGDSHDAC3HDAC4 | |
| SCHEMBL4553739 | 0.75 | C3AR1 (0.45) | C3AR1HPGDSTP53MAPTSMN1; SMN2 | |
| SCHEMBL4430789 | 0.72 | C3AR1 (0.42) | C3AR1RXFP1HDAC3HDAC4HDAC1 | |
| SCHEMBL11095520 | 0.71 | MEN1 (0.49) | MAPTHDAC1HDAC6 | |
| SCHEMBL4993250 | 0.69 | HPGDS (0.51) | C3AR1HPGDSHDAC3HDAC4HDAC1 | |
| SCHEMBL27793044 | 0.69 | C3AR1 (0.74) | C3AR1 | |
| SCHEMBL4425908 | 0.69 | C3AR1 (0.74) | C3AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188528-A1 | Modulators of C3a receptor and methods of use thereof | ENCYSIVE PHARMACEUTICALS, INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188528-A1 | Modulators of C3a receptor and methods of use thereof | C3AR1, C5, C5AR1 | C3AR1 1/4885ROCK2 2946/4885HPGDS 915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.