Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 13/20 | 0.45 |
| ▸ | MAOA | P21397 | 12/20 | 0.45 |
| ▸ | MAOB | P27338 | 12/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27656059 | 0.98 | KDM1A (0.46) | KDM1AMAOAMAOBTRPA1SLC18A3 | |
| SCHEMBL5349573 | 0.87 | KDM1A (0.47) | KDM1AMAOAMAOBTRPA1SLC18A3 | |
| SCHEMBL11848620 | 0.82 | KDM1A (0.40) | KDM1AMAOAMAOBTRPA1SLC18A3 | |
| SCHEMBL11849747 | 0.81 | TSHR (0.38) | KDM1ATRPA1SLC18A3TSHRALDH1A1 | |
| SCHEMBL11842055 | 0.80 | SLC6A2 (0.38) | TRPA1SLC18A3TSHR | |
| SCHEMBL28766998 | 0.77 | SLC18A3 (0.55) | KDM1AMAOAMAOBTRPA1SLC18A3 | |
| SCHEMBL10407205 | 0.77 | KDM1A (0.36) | KDM1AMAOAMAOBTRPA1SLC18A3 | |
| SCHEMBL8323357 | 0.77 | TSHR (0.45) | KDM1AMAOAMAOBTRPA1SLC18A3 | |
| SCHEMBL4984854 | 0.76 | ALDH1A1 (0.41) | TSHRALDH1A1GAA | |
| SCHEMBL27530004 | 0.75 | KDM1A (0.44) | KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345096-B2 | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms | WYETH (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1687288-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005037809-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |