Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943570 | 1.00 | HTR6 (0.53) | HTR6BRD4APPNPC1HSP90AA1 | |
| SCHEMBL4943514 | 0.93 | F2R (0.48) | HTR6ERBB2EPHX2NR1H4SERPINE1 | |
| SCHEMBL15627017 | 0.89 | APP (0.50) | HTR6BRD4APPNPC1HSP90AA1 | |
| SCHEMBL4942437 | 0.88 | ERBB2 (0.48) | HTR6ERBB2EPHX2NR1H4SERPINE1 | |
| SCHEMBL4942869 | 0.87 | HTR6 (0.62) | HTR6BRD4APPNPC1HSP90AA1 | |
| SCHEMBL5795018 | 0.87 | HTR6 (0.62) | HTR6BRD4APPNPC1HSP90AA1 | |
| SCHEMBL28813607 | 0.87 | ERBB2 (0.48) | HTR6ERBB2EPHX2NR1H4SERPINE1 | |
| SCHEMBL4943561 | 0.86 | ERBB2 (0.58) | HTR6APPNPC1HSP90AA1ERBB2 | |
| SCHEMBL27976621 | 0.86 | HDAC6 (0.53) | HSP90AA1ERBB2EPHX2NR1H4SERPINE1 | |
| SCHEMBL27637286 | 0.85 | SERPINE1 (0.44) | HTR6ERBB2EPHX2NR1H4SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368471-B2 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2008-05-06 | — | — | US | disclosed |
| EP-1844771-A2 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | Wyeth (US) | 2007-10-17 | — | — | EP | disclosed |
| US-7074817-B2 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | WYETH (US) | 2006-07-11 | — | — | US | disclosed |