Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990127 | 1.00 | HRH4 (0.46) | HRH4HTR3AHTR6ADORA2AADORA1 | |
| SCHEMBL604138 | 0.85 | HRH4 (0.62) | HRH4HTR3AHTR6ROCK1 | |
| Hydrochloric Acid SCHEMBL603875 | 0.84 | HRH4 (0.61) | HRH4HTR3AHTR6ROCK1DPP4 | |
| SCHEMBL4999115 | 0.82 | HRH4 (0.46) | HRH4HTR3AADORA2AADORA1ROCK1 | |
| SCHEMBL4999125 | 0.82 | HRH4 (0.46) | HRH4HTR3AADORA2AADORA1ROCK1 | |
| SCHEMBL4990134 | 0.72 | HTR3A (0.43) | HRH4HTR3A | |
| SCHEMBL605819 | 0.71 | HRH4 (0.59) | HRH4HTR3AROCK1 | |
| SCHEMBL605820 | 0.71 | HRH4 (0.59) | HRH4HTR3AROCK1 | |
| SCHEMBL605818 | 0.71 | HRH4 (0.59) | HRH4HTR3AROCK1 | |
| SCHEMBL4999121 | 0.70 | HTR3A (0.42) | HRH4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194577-A1 | Antiallergens; asthma; autoimmune disease; pruritius; antiarthritic agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194577-A1 | Antiallergens; asthma; autoimmune disease; pruritius; antiarthritic agents | HRH4, HRH2, HRH3 | HRH4 1/4885HTR3A 333/4885HTR6 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.