Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788345 | 0.91 | REN (0.38) | RENP2RX7CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL498977 | 0.91 | REN (0.38) | RENP2RX7CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL8084854 | 0.89 | REN (0.45) | RENP2RX7CYP3A4CCKBR | |
| SCHEMBL499745 | 0.86 | REN (0.39) | RENCYP3A4SLC6A2SLC6A4KDM4E | |
| SCHEMBL498194 | 0.83 | REN (0.53) | RENCYP3A4 | |
| SCHEMBL498909 | 0.83 | REN (0.53) | RENCYP3A4 | |
| SCHEMBL499068 | 0.82 | REN (0.51) | RENCYP3A4 | |
| SCHEMBL498969 | 0.81 | REN (0.42) | RENCYP3A4SLC6A2SLC6A4 | |
| SCHEMBL499022 | 0.79 | REN (0.54) | RENCYP3A4 | |
| SCHEMBL499005 | 0.79 | REN (0.52) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | claimed |
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |