Metopimazine

Metopimazine

SCHEMBL49905

CS(=O)(=O)c1ccc2c(c1)N(CCCN1CCC(C(N)=O)CC1)c1ccccc1S2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 8/20 1.00
DRD2 P14416 7/20 1.00
HRH1 P35367 7/20 1.00
SLC6A2 P23975 7/20 0.73
ADRA2A P08913 6/20 0.73
DRD1 P21728 6/20 0.73
SLC6A4 P31645 6/20 0.73
ADRA2B P18089 5/20 0.73
ADRA2C P18825 5/20 0.73
HTR2A P28223 5/20 0.73
CYP2D6 P10635 4/20 0.73
HTR2C P28335 4/20 0.73
HTR2B P41595 4/20 0.73
CHRM5 P08912 2/20 0.73
ADRA1D P25100 2/20 0.73
HTR6 P50406 2/20 0.73
SIGMAR1 Q99720 2/20 0.73
HTR1A P08908 6/20 0.60
ADRA1A P35348 6/20 0.60
SLC6A3 Q01959 6/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Metopimazine SCHEMBL30038347 1.00 DRD3 (1.00) DRD3DRD2HRH1SLC6A2ADRA2A
Metopimazine SCHEMBL29462317 1.00 DRD3 (1.00) DRD3DRD2HRH1SLC6A2ADRA2A
Metopimazine SCHEMBL22645258 0.98 DRD3 (0.96) DRD3DRD2HRH1SLC6A2ADRA2A
Metopimazine SCHEMBL22645257 0.97 DRD3 (0.95) DRD3DRD2HRH1SLC6A2ADRA2A
Metopimazine SCHEMBL13724685 0.93 DRD3 (0.87) DRD3DRD2HRH1SLC6A2ADRA2A
SCHEMBL24570751 0.93 DRD3 (0.86) DRD3DRD2HRH1SLC6A2ADRA2A
SCHEMBL15857644 0.91 DRD2 (1.00) DRD3DRD2HRH1SLC6A2ADRA2A
SCHEMBL30467248 0.87 DRD2 (0.79) DRD3DRD2HRH1SLC6A2ADRA2A
SCHEMBL15847810 0.87 DRD2 (0.79) DRD3DRD2HRH1SLC6A2ADRA2A
SCHEMBL21473954 0.86 DRD2 (0.79) DRD3DRD2HRH1SLC6A2ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3285 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025122610-A1 THERAPEUTIC COMBINATIONS AND METHODS FOR 5-HT3 RECEPTOR MODULATORS IN TREATING VARIOUS DISORDERS SEROTONIX LLC (US) 2025-06-12 WO claimed
US-20240366639-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO INC (US) 2024-11-07 US claimed
US-20240156832-A1 METHODS OF METABOLIZING METOPIMAZINE AND ITS SALTS NEUROGASTRX, INC. 2024-05-16 US claimed
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER PEPKON SAS (FR) 2023-12-28 US claimed
US-11834445-B2 Polymorphic forms of metopimazine NEUROGASTRX, INC. (US) 2023-12-05 US claimed
EP-4271385-A1 METHODS OF METABOLIZING METOPIMAZINE AND ITS SALTS Neurogastrx, Inc. (US) 2023-11-08 EP claimed
US-20230142366-A1 NOVEL POLYMORPHIC FORMS OF METOPIMAZINE NEUROGASTRX, INC. 2023-05-11 US claimed
WO-2023049482-A1 METHODS OF TREATING RESTRICTIVE EATING DISORDERS ARVID THERAPEUTICS (US) 2023-03-30 WO claimed
US-20230086867-A1 POLYMORPHIC FORMS OF METOPIMAZINE NEUROGASTRX, INC. 2023-03-23 US claimed
WO-2023016546-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. (US) 2023-02-16 WO claimed
US-6121276-A ORALLY ADMINISTERING DSAGE OF APOMORPHINE TOGETHER WITH ANTIEMETIC PRIOR TO INTERCOURSE; SIDE EFFECT REDUCTION PENTECH PHARMACEUTICALS, INC. (US) 2000-09-19 US claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
WO-2000035457-A1 USE OF APOMORPHINE IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ORGANIC ERECTILE DYSFUNCTION IN MALES ABBOTT LABORATORIES (US) 2000-06-22 WO claimed
WO-1999066916-A1 APOMORPHINE-CONTAINING DOSAGE FORMS FOR AMELIORATING MALE ERECTILE DYSFUNCTION PENTECH PHARMACEUTICALS, INC. (US) 1999-12-29 WO claimed
CN-1203527-A Stable freeze-dried pharmaceutical formulation SANOFI SA (FR) 1998-12-30 CN claimed
EP-0858325-A1 STABLE FREEZE-DRIED PHARMACEUTICAL FORMULATION SANOFI (FR) 1998-08-19 EP claimed
WO-1997017064-A1 STABLE FREEZE-DRIED PHARMACEUTICAL FORMULATION SANOFI (FR) 1997-05-15 WO claimed
EP-0123585-B1 TRANSDERMAL DRUG FORM RHONE-POULENC SANTE (FR) 1988-08-31 EP claimed
US-4746509-A DISPERSION IN FILM-FORMING POLYMER RHONE-POULENC SANTE (FR) 1988-05-24 US claimed
EP-0123585-A2 Transdermal drug form RHONE-POULENC SANTE (FR) 1984-10-31 EP claimed