Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000762 | 0.83 | DHPS (0.60) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL2998761 | 0.82 | DHPS (0.62) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL5812457 | 0.81 | DHPS (0.58) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL23952349 | 0.79 | SMN1; SMN2 (0.89) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL29657194 | 0.77 | GRM5 (0.64) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL5202887 | 0.77 | DHPS (0.54) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| Hydrochloric Acid SCHEMBL16268410 | 0.76 | GRM5 (0.45) | SMN1; SMN2LMNAL3MBTL1ALDH1A1HTT | |
| SCHEMBL5864048 | 0.75 | DHPS (0.58) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL5201380 | 0.75 | DRD3 (0.54) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL5946819 | 0.73 | GRM5 (0.67) | DHPSGRM5POLBDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402596-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2008-07-22 | — | — | US | claimed |