⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512058 | 0.68 | POLB (0.31) | — | |
| SCHEMBL2096975 | 0.57 | — | — | |
| SCHEMBL5438607 | 0.57 | — | — | |
| SCHEMBL20185030 | 0.54 | — | — | |
| SCHEMBL4371554 | 0.53 | — | — | |
| SCHEMBL20298922 | 0.53 | — | — | |
| SCHEMBL7015002 | 0.53 | — | — | |
| SCHEMBL9515906 | 0.53 | — | — | |
| SCHEMBL2094941 | 0.52 | NOTUM (0.41) | — | |
| SCHEMBL9162666 | 0.52 | KDM4E (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188518-A1 | 5-Substituted Imidazoles | ASTRA ZENECA AB (SE) | 2008-08-07 | — | — | US | disclosed |
| US-7384954-B2 | 4-substituted imidazoles | ASTRAZENECA AB (SE) | 2008-06-10 | — | — | US | disclosed |
| US-20070105896-A1 | 4-Substituted imidazoles | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | US | disclosed |
| EP-1687303-A1 | 4-SUBSTITUTED IMIDAZOLES | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | disclosed |
| EP-1687302-A1 | 5-SUBSTITUTED IMIDAZOLES | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049611-A1 | 5-SUBSTITUTED IMIDAZOLES | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005049612-A1 | 4-SUBSTITUTED IMIDAZOLES | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | disclosed |