⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527181 | 0.68 | HIPK2 (0.37) | — | |
| SCHEMBL7015002 | 0.65 | — | — | |
| SCHEMBL1581968 | 0.64 | NOTUM (0.42) | — | |
| SCHEMBL7972 | 0.63 | MEN1 (0.31) | — | |
| SCHEMBL27607780 | 0.63 | CYP3A4 (0.48) | — | |
| SCHEMBL6512058 | 0.61 | POLB (0.31) | — | |
| SCHEMBL16516316 | 0.61 | — | — | |
| SCHEMBL27561216 | 0.61 | MGLL (0.37) | — | |
| SCHEMBL2094941 | 0.60 | NOTUM (0.41) | — | |
| SCHEMBL28183364 | 0.60 | CYP3A4 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229329-B1 | BENZAZEPINE DERIVATIVES | E.R. Squibb & Sons, Inc. (US) | 1993-07-28 | — | — | EP | claimed |
| WO-2024023128-A1 | NOVEL 7-SUBSTITUTED INDOLE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-01 | — | — | WO | disclosed |
| US-10676468-B2 | N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs as hedgehog pathway inhibitors and use thereof | IMPACT THERAPEUTICS, INC. (CN) | 2020-06-09 | — | — | US | disclosed |
| EP-3536320-A1 | APPLICATION OF HEDGEHOG PATHWAY INHIBITOR FOR TREATMENT OF FIBROTIC DISEASES | Impact Therapeutics, Inc (CN) | 2019-09-11 | — | — | EP | disclosed |
| US-20190255042-A1 | APPLICATION OF HEDGEHOG PATHWAY INHIBITOR IN TREATING FIBROSIS DISEASES | Impact Therapeutics (Shanghai), Inc (CN) | 2019-08-22 | — | — | US | disclosed |
| US-20150191460-A1 | N-(3-heteroarylaryl)-4-arylarylcarboxamides and Analogs as Hedgehog Pathway Inhibitors and Use Thereof | IMPACT THERAPEUTICS, INC. (CN) | 2015-07-09 | — | — | US | disclosed |
| EP-2875005-A1 | N-(3-HETEROARYLARYL)-4-ARYLARYLCARBOXAMTDES AND ANALOGS AS HEDGEHOG PATHWAY INHIBITORS AND USE THEREOF | Impact Therapeutics, Inc. (CN) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014012511-A1 | N-(3-HETEROARYLARYL)-4-ARYLARYLCARBOXAMTDES AND ANALOGS AS HEDGEHOG PATHWAY INHIBITORS AND USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2014-01-23 | — | — | WO | disclosed |