Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4995140 | 0.92 | CSNK1D (0.49) | CYP11B1CYP11B2PIM2ROCK2ROCK1 | |
| SCHEMBL5003429 | 0.90 | KDM4E (0.51) | MAPTNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL4996961 | 0.90 | MEN1 (0.51) | MAPTNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL4994785 | 0.88 | SLC6A2 (0.47) | MAPTALDH1A1GAASMN1; SMN2PIM2 | |
| SCHEMBL4997588 | 0.87 | PIM2 (0.52) | MAPTALDH1A1HTTSMN1; SMN2CYP11B1 | |
| SCHEMBL4997668 | 0.87 | NPC1 (0.58) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4993281 | 0.86 | MAPT (0.54) | MAPTNPC1ALDH1A1GAAHPGD | |
| SCHEMBL5003394 | 0.85 | HTR3A (0.44) | NPC1CYP11B1CYP11B2PIM2ROCK2 | |
| SCHEMBL4994089 | 0.85 | NPSR1 (0.47) | MAPTALDH1A1SMN1; SMN2PIM2LMNA | |
| SCHEMBL4992059 | 0.84 | POLB (0.51) | MAPTNPC1ALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | MAPT 5/4885NPC1 2008/4885ALDH1A1 1034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.