Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4992090 | 0.89 | ALDH1A1 (0.48) | CHEK1MAPTALDH1A1HPGDNPC1 | |
| SCHEMBL5000721 | 0.88 | MAPT (0.45) | CHEK1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4993281 | 0.86 | MAPT (0.54) | CHEK1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5000864 | 0.86 | RAD52 (0.44) | MAPTALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL4996260 | 0.85 | CHEK1 (0.48) | CHEK1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4997452 | 0.83 | MAPT (0.45) | MAPTALDH1A1GAAHSD17B10KDM4E | |
| SCHEMBL4996338 | 0.83 | MAPT (0.49) | MAPTALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4995465 | 0.83 | MAPT (0.46) | MAPTALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL5000692 | 0.83 | NPC1 (0.53) | CHEK1MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5003424 | 0.82 | MAPT (0.43) | CHEK1MAPTALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | AURKA 1799/4885CHEK1 1668/4885MAPT 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.