Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.56 |
| ▸ | CDK2AP1 | O14519 | 8/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4994947 | 0.98 | CHEK1 (0.59) | CHEK1CDK2AP1USP30 | |
| SCHEMBL4219757 | 0.98 | CHEK1 (0.59) | CHEK1CDK2AP1USP30 | |
| SCHEMBL5004721 | 0.98 | CHEK1 (0.59) | CHEK1CDK2AP1USP30 | |
| SCHEMBL5001091 | 0.94 | CHEK1 (0.55) | CHEK1CDK2AP1USP30 | |
| SCHEMBL5001062 | 0.94 | CHEK1 (0.58) | CHEK1CDK2AP1USP30 | |
| SCHEMBL4991807 | 0.91 | CHEK1 (0.61) | CHEK1CDK2AP1USP30 | |
| SCHEMBL1563534 | 0.91 | CHEK1 (0.68) | CHEK1CDK2AP1USP30 | |
| SCHEMBL4219520 | 0.91 | CHEK1 (0.59) | CHEK1CDK2AP1 | |
| SCHEMBL5820429 | 0.89 | USP30 (0.53) | CHEK1CDK2AP1USP30 | |
| SCHEMBL4212172 | 0.89 | USP30 (0.52) | CHEK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423061-B2 | Substitute thiophenes and uses thereof | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| US-20060281666-A1 | Substitute thiophenes and uses therof | ASTRAZENECA AB (SE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281666-A1 | Substitute thiophenes and uses therof | TYMP, TPMT, MGMT | CHEK1 602/4885CDK2AP1 2225/4885USP30 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.