Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.48 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5004721 | 0.92 | CHEK1 (0.59) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL4219757 | 0.92 | CHEK1 (0.59) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL4994947 | 0.92 | CHEK1 (0.59) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL4994970 | 0.89 | CHEK1 (0.56) | USP30CHEK1CDK2AP1 | |
| SCHEMBL5001091 | 0.87 | CHEK1 (0.55) | USP30CHEK1PARP1ALDH1A1CDK2AP1 | |
| SCHEMBL4991807 | 0.85 | CHEK1 (0.61) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL4212172 | 0.85 | USP30 (0.52) | USP30CHEK1PBKHDAC4HDAC6 | |
| SCHEMBL5001102 | 0.84 | USP30 (0.43) | USP30CHEK1PBKHDAC4HDAC6 | |
| SCHEMBL5001062 | 0.83 | CHEK1 (0.58) | USP30CHEK1CDK2AP1 | |
| SCHEMBL4219520 | 0.83 | CHEK1 (0.59) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | AstraZeneca AB (SE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016909-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | WO | disclosed |